Annals of Occupational Hygiene Advance Access published online on September 19, 2006
Annals of Occupational Hygiene, doi:10.1093/annhyg/mel062
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, Cincinnati, OH, USA
* To whom correspondence should be addressed. In the spring and summer of 2001, 47 fathers, 48 mothers and 117 children of Iowa farm and non-farm households were recruited to participate in a study investigating take-home pesticide exposure. On two occasions
Received March 10, 2006
Accepted July 17, 2006
Article
Urinary Pesticide Concentrations Among Children, Mothers and Fathers Living in Farm and Non-Farm Households in Iowa
Brian D. Curwin 1 *, Misty J. Hein 1, Wayne T. Sanderson 2, Cynthia Striley 3, Dick Heederik 4, Hans Kromhout 4, Stephen J. Reynolds 5, and Michael C. Alavanja 6
2 University of Iowa, Department of Occupational and Environmental Health, Iowa City, IA, USA
3 National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, OH, USA
4 Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
5 Colorado State University, Department of Environmental and Radiological Health Sciences, Fort Collins, CO, USA
6 National Cancer Institute, Division of Cancer Epidemiology and Genetics, Rockville, MD, USA
Brian D. Curwin, E-mail: bcurwin{at}cdc.gov
Abstract 
1 month apart, urine samples from each participant and dust samples from various rooms were collected from each household and were analyzed for atrazine, metolachlor, glyphosate and chlorpyrifos or their metabolites. The adjusted geometric mean (GM) level of the urine metabolite of atrazine was significantly higher in fathers, mothers and children from farm households compared with those from non-farm households (P 
0.0001). Urine metabolites of chlorpyrifos were significantly higher in farm fathers (P = 0.02) and marginally higher in farm mothers (P = 0.05) when compared with non-farm fathers and mothers, but metolachlor and glyphosate levels were similar between the two groups. GM levels of the urinary metabolites for chlorpyrifos, metolachlor and glyphosate were not significantly different between farm children and non-farm children. Farm children had significantly higher urinary atrazine and chlorpyrifos levels (P = 0.03 and P = 0.03 respectively) when these pesticides were applied by their fathers prior to sample collection than those of farm children where these pesticides were not recently applied. Urinary metabolite concentration was positively associated with pesticide dust concentration in the homes for all pesticides except atrazine in farm mothers; however, the associations were generally not significant. There were generally good correlations for urinary metabolite levels among members of the same family.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. K. Ross, T. L. Jones, and N. M. Filipov Disposition of the Herbicide 2-Chloro-4-(ethylamino)-6-(isopropylamino)-s-triazine (Atrazine) and Its Major Metabolites in Mice: A Liquid Chromatography/Mass Spectrometry Analysis of Urine, Plasma, and Tissue Levels Drug Metab. Dispos., April 1, 2009; 37(4): 776 - 786. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Ritz and R. P. Rull Assessment of environmental exposures from agricultural pesticides in childhood leukaemia studies: challenges and opportunities Radiat Prot Dosimetry, December 1, 2008; 132(2): 148 - 155. [Abstract] [Full Text] [PDF]
|
|