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Annals of Occupational Hygiene Advance Access published online on September 23, 2006
Annals of Occupational Hygiene, doi:10.1093/annhyg/mel055
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© The Author 2006. Published by Oxford University Press on behalf of the British Occupational Hygiene Society
Received March 29, 2006
Accepted June 27, 2006

Article

Collection, Validation and Generation of Bitumen Fumes for Inhalation Studies in Rats Part 3: Regeneration of Bitumen Fumes, Inhalation Setup, Validation

G. Pohlmann 1 *, A. Preiss 1, W. Koch 1, H. Kock 1, M. Elend 1, and M. Raabe 1

1 Fraunhofer Institute of Toxicology und Experimental Medicine, Nikolai-Fuchs-Strasse 1, 30625 Hannover, Germany

* To whom correspondence should be addressed.
G. Pohlmann, E-mail: pohlmann{at}item.fhg.de


  Abstract

Undertaking a chronic inhalation study on bitumen fume presents a challenge in terms of generating sufficient amounts of representative fume. The objective of the study described in this and in previous publications was to collect sufficient fume and use this to develop a laboratory-generated exposure atmosphere, for use in chronic inhalation toxicity studies in rats that resembles, as closely as possible, personal exposures seen in workers during road paving operation. To achieve this goal, atmospheric workplace samples were collected at road paving work sites and compared with bitumen fume condensate samples collected from the headspace of hot bitumen storage tanks. In Parts 1 and 2, we described the collection and analysis of workplace samples, the strategy for in-line extraction of a suitable fraction of bitumen fume collected from the headspace of a bitumen storage tank and the comparison of the collected condensate to the workplace samples. This paper (part 3) describes the regeneration of bitumen fume for inhalation and the exposure setup used for inhalation studies.


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