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Annals of Occupational Hygiene Advance Access published online on February 9, 2005
Annals of Occupational Hygiene, doi:10.1093/annhyg/meh106
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© 2005 British Occupational Hygiene Society
Received July 7, 2004
Accepted December 3, 2004

Article

Worker Exposures to Triclopyr: Risk Assessment Through Measurements in Urine Samples

Nathalie H. Gosselin 1, Robert C. Brunet 2, Gaétan Carrier 1*, and Amssétou Dosso 1

1 Chaire en analyse des risques toxicologiques pour l'humain and Département de santé environnementale et santé au travail, Faculté de Médecine, Université de Montréal, P.O. Box 6128, Main Station, Montreal, Quebec, Canada H3C 3J7
2 Département de Mathématiques et de Statistique and Centre de Recherches Mathématiques, Faculté des arts et des sciences, Université de Montréal, P.O. Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7

* To whom correspondence should be addressed.
Gaétan Carrier, E-mail: gaetan.carrier{at}umantreal.ca


  Abstract

In the province of Quebec (Canada), the phytocide Garlon 4®, whose active ingredient is triclopyr, is often used to prevent trees from reaching electrical conductors. The object of this paper is to assess the potential health risks in workers coming into contact with Garlon 4®. Ten workers collected their urine during the 22 h following the beginning of a work shift. Measured urinary amounts of triclopyr varied between 1 and 13 mg. The absorbed daily doses were estimated from the amounts of triclopyr in urine through the use of a kinetic model that links the rates of triclopyr elimination to absorbed doses. These estimated doses were compared with the no-observed-effect level (NOEL) observed in rats: 5 mg per kg of body weight. The upper-bound estimations of the worker's daily absorbed doses were found to be 13.3% or less of the rat NOEL.


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