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Annals of Occupational Hygiene Advance Access published online on May 17, 2004
Annals of Occupational Hygiene, doi:10.1093/annhyg/meh022
Copyright © 2004 by the British Occupational Hygiene Society.
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Received August 26, 2003
Accepted November 13, 2003

Article

Mesothelioma and Lung Cancer Among Motor Vehicle Mechanics: a Meta-analysis

Michael Goodman 1*, M. Jane Teta 2, Patrick A. Hessel 3, David H. Garabrant 4, Valerie A. Craven 5, Carolyn G. Scrafford 6, Michael A. Kelsh 7

1 Emory University Rollins School of Public Health, 1518 Clifton Road NE, Atlanta, GA 30322, USA
2 Exponent Health Group, 1730 Rhode Island Avenue NW, Suite 1100, Washington, DC 20036, USA
3 Exponent Health Group, 2 North Riverside Plaza, Suite 1400, Chicago, IL 60606, USA
4 University of Michigan School of Public Health, 1420 Washington Heights, Room 6529, Ann Arbor, MI 48109-2029, USA
5 Exponent Health Risk Group, 631 First Street, Santa Rosa, CA 95404, USA
6 Exponent Food and Chemicals Group, 1730 Rhode Island Avenue NW, Suite 1100, Washington, DC 20036, USA
7 Exponent Health Group, 149 Commonwealth Drive, Menlo Park, CA 94025, USA

* To whom correspondence should be addressed. E-mail: mgoodm2{at}sph.emory.edu.


  Abstract

We conducted a systematic review and analysis of the epidemiological literature that examines the risk of lung cancer and mesothelioma among motor vehicle mechanics who may have been engaged in brake repair and, thus, were potentially exposed to asbestos. All relevant studies were classified into three tiers according to their quality. Tier III (lowest quality) studies were cited for completeness, but were not included in the meta-analysis. Meta relative risks (meta-RRs) were calculated for mesothelioma and lung cancer using both fixed and random effects models for Tiers I and II, separately, followed by stratified analyses based on study design or exposure characterization (garage workers versus brake workers) and, for lung cancer studies, based on adequate adjustment for smoking. The meta-analysis for Tier I (higher quality) and Tier II (lower quality) studies of mesothelioma yielded RR estimates of 0.92 (95% CI 0.55-1.56) and 0.81 (95% CI 0.52-1.28), respectively. Further stratification according to exposure characterization did not affect the results. The meta-analysis for lung cancer produced RR estimates of 1.07 (95% CI 0.88-1.31) for Tier I and 1.17 (95% CI 1.01-1.36) for Tier II. When the lung cancer analysis was limited to studies that used adequate control for smoking, the resulting RR estimate was 1.09 (95% CI 0.92-1.28). Based on these findings, we conclude that employment as a motor vehicle mechanic does not increase the risk of developing mesothelioma. Although some studies showed a small increase in risk of lung cancer among motor vehicle mechanics, the data on balance do not support a conclusion that lung cancer risk in this occupational group is related to asbestos exposure.


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