Skip Navigation


Annals of Occupational Hygiene Advance Access originally published online on August 26, 2005
Annals of Occupational Hygiene 2005 49(8):711-718; doi:10.1093/annhyg/mei039
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
49/8/711    most recent
mei039v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (2)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by NYGREN, O.
Right arrow Articles by ERIKSSON, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by NYGREN, O.
Right arrow Articles by ERIKSSON, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© 2005 British Occupational Hygiene Society Published by Oxford University Press

Original Article

A Test Method for Assessment of Spill and Leakage From Drug Preparation Systems

OLLE NYGREN1,*, BENGT GUSTAVSSON2 and ROBERT ERIKSSON3

1 National Institute for Working Life, Department of Work and the Physical Environment, PO Box 7654, SE-907 13 Umeå, Sweden; 2 Division for General Surgery, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden; 3 Radiophysiological Department, Sahlgrenska University Hospital/Östra, SE-416 85 Gothenburg, Sweden

* Author to whom correspondence should be addressed. Tel: +4690-17-60-39; fax: +4690-17-61-23; e-mail: olle.nygren{at}arbetslivsinstitutet.se

Anti-cancer drugs are reactive compounds with known adverse health effects. To prevent occupational exposure to these drugs, there are, in most countries, regulations for handling anti-cancer drugs. Many preparation systems are available, e.g. isolators, biological safety cabinets (BSCs), filter spikes (venting spikes with micro-pore filter) and closed systems (e.g. PhaSealTM). Although these systems are used, there are reports of exposure. This causes concern over how efficient these systems are to prevent spill and leakage that may cause undesired exposure when handling cytotoxic drugs. Today, this knowledge is lacking. This paper presents a method (Tc-method) for testing drug preparation systems for spill and leakage. The Tc-method is based on 99Tcm as a tracer, with which drug vials used for test preparations are spiked. Wipe samples are then collected around the working area to measure spill and leakage. The Tc-method has been validated using an independent method, showing good agreement between the methods. Spills down to 1 nl cm–2 can be determined. In an appendix, the Tc-method is described in a detailed step-by-step procedure.

Keywords: drug leakage • preparation and administration systems • technetium • test method


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ANN OCCUP HYGHome page
O. Nygren, E. Olofsson, and L. Johansson
Spill and Leakage Using a Drug Preparation System Based on Double-Filter Technology
Ann. Hyg., March 1, 2008; 52(2): 95 - 98.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.