Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (10)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Browne, K.
Right arrow Articles by Gee, J. B. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Browne, K.
Right arrow Articles by Gee, J. B. L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Ann. occup. Hyg., Vol. 44, No. 4, pp. 239-250, 2000
© 2000 British Occupational Hygiene Society
Published by Oxford University Press

Asbestos exposure and laryngeal cancer

Kevin Browne and J. Bernard L. Gee

2 Burnham Road, North Creake, Norfolk NR21 9JP, UK Department of Internal Medicine, Yale University School of Medicine, P.O. Box 208057, Newhaven, CT 06520-8057, USA

Tel.: +441328 738129; Fax: +441328 730227

Received 16 June, 1999; Revised 11 October, 1999.

Objective: To carry out a systematic review of the evidence relating asbestos exposure to the risk of laryngeal cancer.

Method: All identified studies of asbestos workers providing data on laryngeal disease were reviewed, together with studies of laryngeal cancers giving epidemiological or experimental evidence of associated exposures.

Results: Confounding due to smoking and alcohol intake, and to a lesser extent diet and socio-economic factors, creates a major difficulty over the identification of any asbestos or other occupational effect. Not only are smoking and alcohol independently associated with large increases in relative risk (RR) of laryngeal cancer, but also have a synergistic effect with each other. Few of the studies provide details of either habit. Among 24 prospective studies for which a standardized mortality ratio (SMR) was available, nine had an SMR at or below unity, and among a further 11 without an SMR for comparison, in only one was there a clear excess risk. In 17 retrospective studies, only two showed a significantly increased RR. Evidence from animal experiments, studies of associations with pleural plaques, and autopsy findings also appear negative or inconclusive.

Conclusion: The evidence does not indicate that asbestos exposure increases the RR of laryngeal cancer.

asbestos; cancer; laryngeal cancer


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ChestHome page
D. E. Banks, R. Shi, J. McLarty, C. T. Cowl, D. Smith, S. M. Tarlo, F. Daroowalla, J. Balmes, and M. Baumann
American College of Chest Physicians Consensus Statement on the Respiratory Health Effects of Asbestos: Results of a Delphi Study
Chest, June 1, 2009; 135(6): 1619 - 1627.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.