Annals of Occupational Hygiene Advance Access published online on September 16, 2009
Annals of Occupational Hygiene, doi:10.1093/annhyg/mep068
Characterization and Assessment of Dermal and Inhalable Nickel Exposures in Nickel Production and Primary User Industries
1 Exposure Assessment Section, Institute of Occupational Medicine, Edinburgh EH14 4AP, UK
2 Department of Occupational and Environmental Medicine, University of Aberdeen, Aberdeen AB25 2ZP, UK
3 Nickel Producers Environmental Research Association, Durham, NC 27713, USA
* Author to whom correspondence should be addressed. Tel: +44-0-131-449-8000; fax: +44-0-131-449-8084; e-mail: graeme.hughson{at}abdn.ac.uk
The aim of this study was to measure the levels of nickel in the skin contaminant layer of workers involved in specific processes and tasks within the primary nickel production and primary nickel user industries. Dermal exposure samples were collected using moist wipes to recover surface contamination from defined areas of skin. These were analysed for soluble and insoluble nickel species. Personal samples of inhalable dust were also collected to determine the corresponding inhalable nickel exposures. The air samples were analysed for total inhalable dust and then for soluble, sulfidic, metallic, and oxidic nickel species. The workplace surveys were carried out in five different workplaces, including three nickel refineries, a stainless steel plant, and a powder metallurgy plant, all of which were located in Europe. Nickel refinery workers involved with electrolytic nickel recovery processes had soluble dermal nickel exposure of 0.34 µg cm–2 [geometric mean (GM)] to the hands and forearms. The GM of soluble dermal nickel exposure for workers involved in packing nickel salts (nickel chloride hexahydrate, nickel sulphate hexahydrate, and nickel hydroxycarbonate) was 0.61 µg cm–2. Refinery workers involved in packing nickel metal powders and end-user powder operatives in magnet production had the highest dermal exposure (GM = 2.59 µg cm–2 soluble nickel). The hands, forearms, face, and neck of these workers all received greater dermal nickel exposure compared with the other jobs included in this study. The soluble nickel dermal exposures for stainless steel production workers were at or slightly above the limit of detection (0.02 µg cm–2 soluble nickel). The highest inhalable nickel concentrations were observed for the workers involved in nickel powder packing (GM = 0.77 mg m–3), although the soluble component comprised only 2% of the total nickel content. The highest airborne soluble nickel exposures were associated with refineries using electrolytic processes for nickel recovery (GM = 0.04 mg m–3 total nickel, containing 82% soluble nickel) and those jobs involving contact with soluble nickel compounds (GM = 0.02 mg m–3 total nickel content, containing 76% soluble nickel). The stainless steel workers were exposed to low concentrations of relatively insoluble airborne nickel species (GM = 0.03 mg m–3 total nickel, containing 1% soluble nickel). A statistically significant correlation was observed between dermal exposures for all anatomical areas across all tasks. In addition, the dermal and inhalable (total) nickel exposures were similarly associated. Overall, dermal exposures to nickel, nickel compounds, and nickel alloys were relatively low. However, exposures were highly variable, which can be explained by the inconsistent use of personal protective equipment, varying working practices, and different standards of automation and engineering controls within each exposure category.
dermal exposure • dermal exposure assessment • dermal exposure measurement • EASE • EU chemical regulation • exposure assessment for existing substances • inhalable dust • nickel
Received March 30, 2009; in final form August 20, 2009