Annals of Occupational Hygiene Advance Access published online on February 2, 2009
Annals of Occupational Hygiene, doi:10.1093/annhyg/mep003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Measurement Error and Model Specification in Determining How Duration of Tasks Affects Level of Occupational Exposure
Community and Occupational Medicine Program, Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada, T6G 2G3
* Author to whom correspondence should be addressed. Tel: +780-492-3240; fax: +780-492-9677; e-mail: iburstyn{at}ualberta.ca
Statistical modeling of determinants of exposure ascertained in large-scale surveys is an increasingly popular approach to both (i) identifying effective occupational exposure controls that arise in ‘natural experiments’ and (ii) predicting how altering some working conditions may impact exposure levels. This paper sheds light on two underappreciated methodological challenges of such studies. First, I examine the impact of measurement error in the observed determinant of exposure on an investigator's ability to correctly rank the determinants of exposure in terms of their exposure rate (one aspect of how important a give determinant is). Simultaneously, I consider the issue of whether empirical models fitted for the sake of statistical convenience actually reflect the physical reality that is being modeled and how this may affect the answer to the question about ranking determinants of exposure. These general issues are examined in the context of the ‘time per task’ determinant of exposure and true exposure model that states that exposure is equal to product of exposure rate and duration of a task. Simulation studies were conducted and their conclusions applied in re-examining the data on the impact of duration of some key task on exposure levels to flour dust among bakers. The simulation study demonstrated that bias due to measurement error in observed effects can be either positive or negative. The main conclusion is that the correct ranking of exposure rates can be obtained from both true and poorly specified exposure models, but can be severely distorted by errors in estimates of the duration of tasks performed.
determinants of exposure • linear regression • mismeasured covariate • physical model • simulation • statistical model
Received October 27, 2008; in final form January 4, 2009