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Annals of Occupational Hygiene Advance Access originally published online on January 23, 2008
Annals of Occupational Hygiene 2008 52(2):95-98; doi:10.1093/annhyg/mem067
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© 2008 The Author(s).
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Spill and Leakage Using a Drug Preparation System Based on Double-Filter Technology

Olle Nygren1,*, Eva Olofsson2 and Lennart Johansson3

1 Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden
2 Hospital Pharmacy, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden
3 Department of Radio Physics, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden

* Author to whom correspondence should be addressed. Tel: +46-907-865-483; fax: +46-907-867-655; e-mail: olle.nygren{at}chem.umu.se

Occupational exposure to cytotoxic drugs has frequently been reported during recent years. Various drug-handling systems have been applied to reduce the spill and leakage that cause this exposure. Some of these systems have also been tested for spill and leakage using independent test methods. In this paper, a new drug-handling system has been tested for spill and leakage during drug preparation. The handling system, TevadaptorTM, was tested using a modification of an independent test method, the Technetium test method, based on the use of Technetium m-99 as tracer substance. The test results showed that the spill was <100 nl for all 75 preparations and was <1 nl for 70 of the preparations. This is comparable with other tested drug-handling system, e.g. isolators, PhaSealTM. The test shows that the Tevadaptor drug-handling system has similar performance as drug-handling systems regarded as closed systems.

Keywords: drug emission • drug handling • occupational exposure • test methods for preparation systems

Received May 21, 2007; in final form November 29, 2007


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