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Annals of Occupational Hygiene Advance Access originally published online on December 17, 2007
Annals of Occupational Hygiene 2008 52(1):45-54; doi:10.1093/annhyg/mem061
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© The Author 2007. Published by Oxford University Press on behalf of the British Occupational Hygiene Society

Work Area Measurements as Predictors of Personal Exposure to Endotoxin and Cotton Dust in the Cotton Textile Industry

A. J. Mehta1, X. R. Wang1, E. A. Eisen1, H. L. Dai3, G. Astrakianakis4, N. Seixas4, J. Camp4, H. Checkoway4 and D. C. Christiani1,*

1 Department of Environmental Health, Environmental and Occupational Medicine and Epidemiology Program, Harvard School of Public Health, Boston, MA, USA
2 Department of Community and Family Medicine, Chinese University of Hong Kong, Hong Kong, China
3 Putuo District People's Hospital, Shanghai, China
4 Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, USA

* Author to whom correspondence should be addressed. Tel: 617-726-9274; fax: 617-726-2932; e-mail: dchris{at}hsph.harvard.edu

Objectives: To determine if work area measurements of endotoxin and/or cotton dust obtained from the vertical elutriator (VE) can be used to predict levels of personal endotoxin exposure as measured by the Institute of Occupational Medicine (IOM) inhalable dust sampler in the cotton textile industry.

Methods: Fifty-six work area cotton dust samples were collected from 14 areas and 82 personal cotton dust samples were collected from 41 workers in three textile mills (Mills A, B and C) in Shanghai, China. Cotton dust concentrations were determined gravimetrically from sample filters, of which endotoxin concentrations were determined using a kinetic chromogenic modification of the limulus amoebocyte lysate assay. Linear regression models were used to determine the association between log IOM personal endotoxin concentration and log VE area endotoxin concentration.

Results: Median cotton dust and endotoxin concentrations measured from VE area samples in the three mills were 0.36 mg m–3 and 1280.76 endotoxin units per cubic meter (EU m–3), respectively, compared to 1.74 mg m–3 and 2226.83 EU m–3 from IOM personal samples. Excluding samples from weaving processes, we observed linear associations between VE area measures of endotoxin and IOM personal endotoxin concentrations; VE area concentration of endotoxin explained 83 and 89% of the total variation in IOM personal endotoxin concentration for Mills A and B, respectively (Mill A: R2 = 0.83, P < 0.0001; Mill B: R2 = 0.89, P < 0.0001). Although area measures of cotton dust was also a significant predictor of person endotoxin, the model explained less of the variance in personal endotoxin measurements.

Conclusions: Specific to the conditions of the textile mills investigated in this study, work area measurements of endotoxin, but not cotton dust, may be reasonable proxies for personal levels, at least for rank-ordering exposures.

Keywords: cotton dust • endotoxin • exposure assessment • occupational exposure • Shanghai textile workers

Received August 5, 2006; in final form October 9, 2007


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