Annals of Occupational Hygiene Advance Access originally published online on June 15, 2006
Annals of Occupational Hygiene 2006 50(7):705-715; doi:10.1093/annhyg/mel027
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Large Organic Aerosols in a Dynamic and Continuous Whole-Body Exposure Chamber Tested on Humans and on a Heated Mannequin
1 Department of Applied Environmental Science (ITM), Stockholm University Stockholm, Sweden
2 Department of Medicine, Occupational and Environmental Dermatology Karolinska Institutet, Stockholm Sweden
3 Stockholm Centre for Public Health, Stockholm County Council Stockholm, Sweden
4 Department of Medicine, Karolinska Institutet Stockholm, Sweden
*Author to whom correspondence should be addressed. Tel: +46-8-674 7648; fax +46-8-674 7638; e-mail: lennart.lundgren{at}itm.su.se
Exposure to large airborne organic aerosols may cause respiratory and skin symptoms. The use of human exposure chambers permits safe mechanistic studies of the effect of inhalation or dermal deposition of such particles. The performance of a dynamic and continuous whole-body human exposure chamber using turbulent air mixing during exposure to these organic aerosols of humans and of a new heated mannequin was evaluated. Variability of temporal and spatial distribution of the airborne particle concentration, and aerodynamic aerosol size distribution of the inhalable fraction, were evaluated. The temporal and spatial distribution of these aerosols close to the breathing zone during an exposure session was typically 
10%, which is low for airborne particles of this size. In a larger section around a human, only slightly higher spatial variation was found. Variability between exposure sessions was also low (<10%). Only limited effect of relative humidity for the organic aerosols was observed. The aerodynamic particle size distribution curves differed slightly, but some were comparable to those in occupational environments. The outcome of the performance tests as measured with the heated mannequin was almost the same as with humans, indicating that the mannequin could be used in preparatory tests in this type of chamber.
Keywords: exposure chamber • large aerosols • mannequin • organic • particle size • performance • spatial variability • temporal variability
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