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Annals of Occupational Hygiene Advance Access originally published online on May 17, 2005
Annals of Occupational Hygiene 2005 49(6):535-541; doi:10.1093/annhyg/mei015
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Crown Copyright 2005. Reproduced with the Permission of the Controller of Her Majesty's Stationery Office Published by Oxford University Press

Original Article

Internal Contamination of Gloves: Routes and Consequences

B. V. RAWSON1, J. COCKER1,*, P. G. EVANS2, J. P. WHEELER2 and P. M. AKRILL1

1 The Health and Safety Laboratory, Harpur Hill, Buxton SK17 9JN, UK; 2 The Health and Safety Executive, Magdalen House, Bootle L20 3QZ, UK

* Author to whom correspondence should be addressed. Tel: +44 1298 218429; fax: +44 1298 218172; e-mail: john.cocker{at}hsl.gov.uk

The effect of internal glove contamination was investigated using N-methyl pyrrolidone (NMP) as a biological marker to assess systemic absorption when wearing internally contaminated gloves, and when not wearing gloves but subjected to the same challenge contaminant. The routes by which the insides of gloves become contaminated were also investigated. The area of dermal contamination was quantified using a fluorescent tracer dye and a surface monitoring fluorimeter. The main routes of internal glove contamination were found to be self-contamination, cuff entry and failed gloves. Wearing internally contaminated gloves led to higher systemic absorption than was gained from the equivalent skin contamination when not wearing gloves. Repeat wetting of fingers with aqueous NMP, when gloves were not worn, gave higher systemic absorption than the equivalent continuous exposure, probably due to the low volatility of NMP leading to increased concentration and longer residence time on the skin.

Keywords: biological monitoring • dermal contact • gloves • hygiene


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