Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by GOEDE, H. A.
Right arrow Articles by VAN HEMMEN, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GOEDE, H. A.
Right arrow Articles by VAN HEMMEN, J. J.
Social Bookmarking
 Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Ann. occup. Hyg., Vol. 47, No. 8, pp. 609-618, 2003
© 2003 British Occupational Hygiene Society
Published by Oxford University Press

Classification of Dermal Exposure Modifiers and Assignment of Values for a Risk Assessment Toolkit

H. A. GOEDE1,*, S. C. H. A. TIJSSEN1, H. J. SCHIPPER2, N. WARREN3, R. OPPL4, F. KALBERLAH5 and J. J. VAN HEMMEN1

1 Department of Chemical Exposure Assessment, TNO Chemistry, Zeist; 2 ArboUnie Noord Holland West, Alkmaar, The Netherlands; 3 Health and Safety Laboratory, Sheffield, UK; 4 Eurofins Denmark A/S, Galten, Denmark; 5 FoBiG GmbH, Freiburg, Germany

Received 29 January 2003; in final form 12 May 2003

This paper describes how default dermal exposure values can be adjusted with modifier values for specific work situations. The work presented here is supplementary to a toolkit developed for the EU RISKOFDERM project. This toolkit is intended for the assessment and management of dermal risks in small and medium sized enterprises. Potential dermal exposure (on the outer envelope of the body) is estimated with an algorithm whereby modifier values are applied multiplicatively to dermal default exposure values. These exposure modifiers with their assigned factors are intended to increase or decrease the potential (default) dermal exposure accordingly. Default estimates are modified to obtain two modified defaults: potential exposure rate to the hands and to the body. Quantitative exposure data is at present inadequate and insufficient to derive meaningful information that can be used for the selection of independent modifiers and the assignment of appropriate values. Instead, available information from the literature was considered and, in combination with expert judgement, 15 potential dermal modifiers were selected. Modifiers were classified and grouped into non-overlapping groups in order to avoid double scoring. Values were assigned to modifiers in three different exposure routes, i.e. direct contact, surface contact and deposition. Depending on the significance of a modifier, the values assigned to modifiers were weighted in equal steps on a log-scale. The values assigned to modifiers as presented in this paper are open to validation and revision once new data become available.

Keywords: dermal; determinant; exposure variables; modifier; risk assessment; toolkit


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
ANN OCCUP HYGHome page
T. Ogden
REACH--how is it going?
Ann. Hyg., January 1, 2010; 54(1): 1 - 4.
[Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
H. Marquart, H. Heussen, M. Le Feber, D. Noy, E. Tielemans, J. Schinkel, J. West, and D. Van Der Schaaf
'Stoffenmanager', a Web-Based Control Banding Tool Using an Exposure Process Model
Ann. Hyg., August 1, 2008; 52(6): 429 - 441.
[Abstract] [Full Text] [PDF]


Home page
Hum Exp ToxicolHome page
P. Boogaard
Biomonitoring as a tool in the human health risk characterization of dermal exposure
Human and Experimental Toxicology, April 1, 2008; 27(4): 297 - 305.
[Abstract] [PDF]


Home page
ANN OCCUP HYGHome page
N. D. WARREN, H. MARQUART, Y. CHRISTOPHER, J. LAITINEN, and J. J. VAN HEMMEN
Task-based Dermal Exposure Models for Regulatory Risk Assessment
Ann. Hyg., July 1, 2006; 50(5): 491 - 503.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
R. RAJAN-SITHAMPARANADARAJAH, M. ROFF, P. DELGADO, K. ERIKSSON, W. FRANSMAN, J. H. J. GIJSBERS, G. HUGHSON, M. MAKINEN, and J. J. VAN HEMMEN
Patterns of Dermal Exposure to Hazardous Substances in European Union Workplaces
Ann. Hyg., April 1, 2004; 48(3): 285 - 297.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
J. J. VAN HEMMEN
Dermal Exposure to Chemicals
Ann. Hyg., April 1, 2004; 48(3): 183 - 185.
[Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
J. J. VAN HEMMEN, J. AUFFARTH, P. G. EVANS, B. RAJAN-SITHAMPARANADARAJAH, H. MARQUART, and R. OPPL
RISKOFDERM: Risk Assessment of Occupational Dermal Exposure to Chemicals. An Introduction to a Series of Papers on the Development of a Toolkit
Ann. Hyg., November 1, 2003; 47(8): 595 - 598.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
J. MARQUART, D. H. BROUWER, J. H. J. GIJSBERS, I. H. M. LINKS, N. WARREN, and J. J. VAN HEMMEN
Determinants of Dermal Exposure Relevant for Exposure Modelling in Regulatory Risk Assessment
Ann. Hyg., November 1, 2003; 47(8): 599 - 607.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
N. WARREN, H. A. GOEDE, S. C. H. A. TIJSSEN, R. OPPL, H. J. SCHIPPER, and J. J. VAN HEMMEN
Deriving Default Dermal Exposure Values for Use in a Risk Assessment Toolkit for Small and Medium-sized Enterprises
Ann. Hyg., November 1, 2003; 47(8): 619 - 627.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
R. OPPL, F. KALBERLAH, P. G. EVANS, and J. J. VAN HEMMEN
A Toolkit for Dermal Risk Assessment and Management: An Overview
Ann. Hyg., November 1, 2003; 47(8): 629 - 640.
[Abstract] [Full Text] [PDF]


Home page
ANN OCCUP HYGHome page
U. SCHUHMACHER-WOLZ, F. KALBERLAH, R. OPPL, and J. J. VAN HEMMEN
A Toolkit for Dermal Risk Assessment: Toxicological Approach for Hazard Characterization
Ann. Hyg., November 1, 2003; 47(8): 641 - 652.
[Abstract] [Full Text] [PDF]



Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.