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Ann. occup. Hyg., Vol. 46, No. suppl_1, pp. 81-84, 2002
© 2002 British Occupational Hygiene Society
Published by Oxford University Press

Toxicity of Cellulose Fibres

R. T. Cullen*, B. G. Miller, A. D. Jones and J. M. G. Davis

Institute of Occupational Medicine 8 Roxburgh Place, Edinburgh EH8 9SU, UK

*Author to whom correspondence should be addressed. Tel: +44-131-667-5131; fax: +44-131-667-0136; e-mail: richard.cullen{at}iomhq.org.uk

Respirable cellulose fibres were less toxic in vitro than the mineral fibres crocidolite and MMVF10. Short-term inhalation of cellulose caused an inflammatory lung response which resolved despite continuing exposure. Intraperitoneal injection of cellulose fibres induced sarcomas rather than mesotheliomas at the highest dose (109 WHO fibres), while the two middle doses (107 and 108 fibres) each produced a mesothelioma. Further work is required to examine the pulmonary effects of respirable cellulose fibres.

cellulose • crocidolite • fibres • inhalation • inflammation • intraperitoneal injection • MMVF10 • tumour


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