Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jones, A. D.
Right arrow Articles by Davis, J. M. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Jones, A. D.
Right arrow Articles by Davis, J. M. G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Ann. occup. Hyg., Vol. 46, No. suppl_1, pp. 77-80, 2002
© 2002 British Occupational Hygiene Society
Published by Oxford University Press

Apparently Similar Glass Microfibres Show Contrasting Toxicity

A. D. Jones*, B. G. Miller, D. Buchanan, C. A. Soutar, R. T. Cullen and J. M. G. Davis

Institute of Occupational Medicine 8 Roxburgh Place, Edinburgh, UK

*Author to whom correspondence should be addressed.

Previous results from the Colt Fibre Research Programme supported the idea that the number of long thin fibres and their ability to persist in the lung are predictors for the risk of cancer. The results were based on nine fibres, including one glass microfibre (100/475) which had low biological activity. New results with a second glass microfibre (104E) show greater cell proliferation than with 100/475 following short-term inhalation and much greater carcinogenic potential in both chronic inhalation and i.p. experiments, equalling or exceeding that of amosite asbestos. New measurements are used to characterize the durability of the fibres. The extended data still support a dependence of pathogenicity on dose and durability, but with some other factor, perhaps differential leaching affecting surface properties, modifying the relative potency of the two microfibres.

biopersistence • cancers • man-made fibres • inhalation • injection


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.