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Ann. occup. Hyg., Vol. 46, No. suppl_1, pp. 22-26, 2002
© 2002 British Occupational Hygiene Society
Published by Oxford University Press

Importance of Surface Characteristics of Quartz DQ12 for Acute Inflammation

Catrin Albrecht*, Andrea Becker, Roel P. F. Schins, Doris HöHR, Klaus Unfried, AD M. Knaapen and Paul J. A. Borm

Institute of Environmental Research—Particletoxicology Auf'm Hennekamp 50, D-40225 Düsseldorf, Germany

*Author to whom correspondence should be addressed. Tel: +49-211-3389-351l; fax: +49-211-3389-331; e-mail: catrin.albrecht{at}uni-duesseldorf.de

Although quartz is known to induce inflammation in rat lungs, the mechanisms by which it does so are not yet fully understood. The importance of particle surface characteristics was investigated in vivo after intratracheal instillation of different preparations of quartz in rat lungs. Three days after instillation of 2 mg of DQ12 quartz, or DQ12-coated with polyvinylpyridine-N-oxide or aluminium lactate (AL), lungs of female Wistar rats were lavaged in situ to determine markers of inflammation. Control rats received saline or the coating substances alone. DQ12 induced a marked inflammatory response, as indicated by a significant increase in the number of neutrophils and macrophages, as well as in the levels of β-glucuronidase and myeloperoxidase. None of these inflammatory markers was increased for both coated quartz preparations, with the exception of neutrophil influx, which was increased after treatment with AL quartz. Our results indicate that surface characteristics are important in the onset of quartz-induced lung inflammation and, by implication, the development of persistent inflammation. This will be investigated in later follow-up time points of the same animal study.

quartz • DQ12 • inflammation • aluminium lactate


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