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Ann. occup. Hyg., Vol. 46, No. suppl_1, pp. 102-104, 2002
© 2002 British Occupational Hygiene Society
Published by Oxford University Press

Subchronic Studies on Man-Made Vitreous Fibres: Toxicity Results

R. C. Brown1,*, B. Bellmann2, H. Muhle2, H. Ernst2, G. Pohlmann2 and P. Sebastien3

1 Toxicology Services Uppingham UK
2 Fraunhofer Institute of Toxicology and Aerosol Research Nickolai-Fuchs Strasse 1, Hannover, Germany
3 CREE, Rue Jean Monet Zac du Min BP 224 84306, Cedex Cavaillon, France

*Author to whom correspondence should be addressed. e-mail: RB{at}toxservices.demon.co.uk

Two ‘alkaline earth silicate’ wools—a calcium magnesium silicate and a calcium magnesium zirconium silicate—were examined in a subchronic ‘90-day’ rat inhalation assay. A preparation of a high-purity refractory ceramic fibre (RCF), a non-fibrous particulate (NFP) with the same, aluminosilicate chemical composition and a sample of long-fibred amosite were also examined. The assay was similar to that proposed by the European Union but was undertaken before that protocol was finalized. Exposure was to a single fibre concentration only (150 fibres >20 µm long/ml); NFP was used at an equal mass aerosol concentration to that of the RCF. The rats were followed for 1 yr after exposure. Neither of the alkaline earth silicates accumulated in the lung to a sufficient level to cause any significant effect. The non-fibrous particulate produced more inflammation than any of the fibres. All inflammatory effects were proportional to the inhibition of macrophage-mediated particle clearance. As the amosite fibres are thin, this material accumulated to lower mass burden than the man-made fibres. Compared with the man-made fibres, amosite caused less inflammation but more cell proliferation.

subchronic inhalation • man-made fibres • amosite • fibre clearance • non-fibrous particles


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