Ann. occup. Hyg., Vol. 46, No. 6, pp. 555-557, 2002
© 2002 British Occupational Hygiene Society
Published by Oxford University Press
Cisplatin Contamination Observed on the Outside of Drug Vials
1 National Institute for Working Life, Program for Chemical Exposure Assessment, PO Box 7654, SE-907 13 Umeå; 2 Östra Hospital, Surgical Department, SE-416 85 Göteborg; 3 Östra Hospital, Hospital Pharmacy, SE-416 85 Göteborg, Sweden
Received 20 December 2001; in final form 7 May 2002
Exposure to cytotoxic drugs is of great concern today. Special regulations for handling these drugs during preparation and administration have been implemented in most countries. Concern has also been raised as to whether exposure to these drugs can occur due to contaminated drug vials. In this investigation, wipe samples were taken from drug vials used for platinum-containing drugs, e.g. cisplatin and related drugs. The vials were randomly picked from unbroken packages from different manufacturers. The results showed that drug vials may already be contaminated on the outside when delivered from the manufacturer.
Keywords: cytotoxic drugs; vial contamination; cisplatin
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