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Ann. occup. Hyg., Vol. 45, No. 90001, pp. S19-S21, 2001
© 2001 British Occupational Hygiene Society
Published by Oxford University Press

Critique of the paper: could pesticide toxicology studies be more relevant to occupational risk assessment? (by Ross et al., 2001)

Neil G. Carmichael

Aventis CropScience, Sophia AntipolisFrance

Tel.: +33-4-92-94-34-02; Fax: +33-4-93-65-41-39

Received 5 October, 2000; Accepted 27 November, 2000.

The toxicology studies required for the registration of a pesticide are not necessarily well adapted to user safety assessment. This problem can be overcome in some cases by improving the guideline studies. In other cases the guidelines are based on animal models which are poor models for man; the most obvious example is rat percutaneous penetration. In other cases it may simply be impractical to have a model which can be extrapolated to all exposure situations. This is the case for intermittent exposure which is infinitely variable. The general conclusion is that the entire data package should be re-examined to make it more relevant to risk assessment.

risk; occupational; pesticides; dermal pharmacokinetics; intermittent exposure; workers


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